The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field.
Contents
Overview
The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field.
Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development.
The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows.
It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth.
The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease.
The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease.
The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving.
Features:
- Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today’s cancer research and treatment community.
- It is written not only for consultation, but also for easy cover-to-cover reading.
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Book Details – Oxford Textbook of Cancer Biology
Book Details
- Title: Oxford Textbook of Cancer Biology 1st Edition
- Author: David Kerr Francesco Pezzella Mahvash Tavassoli
- Publisher: Oxford University Press
- Publication: 2019
- Edition: 1st Ed
- Language: English
- Book Format: PDF
- Book Series: Oxford Textbooks Oxford Textbooks in Oncology
Table of contents
- Front Matter
- Copyright Page
- Preface
- Acknowledgements
- Abbreviations
- Contributors
- Section I The multicellular organism
- 1 The multicellular organism and cancer
- 2 DNA repair and genome integrity
- 3 Evolution and cancer
- Section II The aetiology of cancer
- 4 Genetics and genetic instability in cancer
- 5 Epigenetics
- 6 Viral carcinogenesis: An overview
- 7 Chemical carcinogens
- 8 Radiation as a carcinogen
- Section III How the cancer cell works
- 9 Growth factors and associated signalling pathways in tumour progression and in cancer treatment
- 10 Hormones and cancer
- 11 Oncogenesis and tumour suppression
- 12 The signalling pathways in cancer
- 13 Cell cycle control
- 14 Cancer and cell death
- 15 Telomerase and immortalization
- 16 Cancer metabolism
- 17 Chaperones and protein quality control in the neoplastic process
- 18 Oxygen and cancer: The response to hypoxia
- 19 Invasion, metastasis, and tumour dormancy
- 20 Cancer stem cells
- Section IV Cancer microenvironment
- 21 Cancer-associated stroma
- 22 Blood vessels and cancer
- 23 Cancer immunology
- Section V Global vision of cancer
- 24 Molecular profiling in cancer research and personalized medicine
- 25 Proteomics and metabolomics applications in cancer biology
- 26 Cancer systems biology: From molecular profiles to pathways, signalling networks, and therapeutic vulnerabilities
- 27 Cancer biology through immunohistology
- Section VI The biology of cancer treatment
- 28 Principles of chemotherapy
- 29 Immunotherapy and tumour resistance to immune-mediated control and elimination
- 30 Biological effect of radiotherapy on cancer cells
- Section VII Conclusions
- 31 Benign tumours: The forgotten neoplasms
- 32 Conclusions: Cancer biology, a moveable feast
- Index
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- Title: Oxford Textbook of Cancer Biology 1st Edition
- Book Format: PDF
- File Size: 157 MB
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This is an excellent overview of cancer biology and advances in the field. The content is current, engaging, easy to understand, and provides a solid foundation for a wide variety of medical and scientific professionals. 5 stars!
– George M Rodgers, Doody’s Reviews
